Biobank projects that have been approved so far
A targeted approach to investigate effects of multiple modifiable environmental factors on autistic traits.
Lead Investigator: Youssef Oulhote
Institution: University of Massachusetts Amherst
Status: Ongoing
This project is measuring associations between prenatal exposure to various chemicals and autistic traits in young children, and also examining whether certain nutrients could be consumed to reduce any harmful effects of the chemical exposures.
Analysis of Chemical Mixtures and Child Development Using Advanced Statistical Methods
Lead Investigator: Aimin Chen
Institution: University of Pennsylvania
Status: Ongoing
Investigating the impact of prenatal and child exposure to a mixture of chemicals including metals such as lead, chemicals found in plastics and other consumer products and flame retardants on child IQ and behavior.
Analysis of heavy and trace metals in maternal whole blood from the MIREC-ENDO study
Lead Investigator: Sara Packull-McCormick
Institution: Health Canada
Status: Ongoing
Analyzing blood samples collected from participating mothers during the MIREC-ENDO follow-up study to determine the concentration of 23 metals.
Assessing time-dependent vulnerability to air pollution and multi-pollutant sector impacts on fetal development in the MIREC study cohort
Lead Investigator: Markey Johnson
Institution: Health Canada (Air Health Science Division)
Status: Ongoing
Identified adverse neonatal health outcomes associated with exposure to air pollution during pregnancy, including lower birth weight and infant respiratory distress, and periods during pregnancy when the infant was most at risk.
Associations between perfluoroalkyl substances (PFAS) and lipids and liver function biomarkers
Lead Investigator: Michael Borghese
Institution: Health Canada
Status: Ongoing
Investigating the potential effects of exposure to perfluoroalkyl substances (PFAS) on selected biomarkers of cardiovascular health and liver function in women during pregnancy and during MIREC-ENDO.
Biochemical assessment of bone health during pre- and peri-menopause: Analysis of human serum from the MIREC-ENDO study
Lead Investigator: Mandy Fisher
Institution: Health Canada
Status: Ongoing
Measuring markers of bone health in women who participated in the most recent MIREC follow-up study, MIREC-ENDO.
Biochemical assessment of maternal stress during pregnancy and association with puberty timing in the MIREC-ENDO study
Lead Investigator: Mandy Fisher
Institution: Health Canada
Status: Ongoing
Measuring steroid hormones in maternal hair samples collected after delivery to investigate the effect of maternal stress on the onset of puberty in their children.
Early life organophosphate ester (OPE) exposures and adiposity and cardiometabolic health during adolescence
Lead Investigator: Ann Vuong
Institution: University of Nevada
Status: Ongoing
Examining whether prenatal exposure to some flame retardants (organophosphate) is associated with cholesterol levels, being overweight and having adverse cardiometabolic health outcomes in adolescence.
Effects of fluoride in tooth dentin on neurodevelopmental outcomes in infants and children in a Canadian Cohort, and examining whether maternal thyroid and immune biomarkers play a role.
Lead Investigator: Christine Till
Institution: York University
Status: Ongoing
Testing whether fluoride exposure in tooth dentin is associated with lower IQ scores in children and testing the association between fluoride levels and thyroid hormones in pregnancy.
Environmental Chemicals and Maternal-Fetal Markers of Diabetes, Obesity and Metabolic Dysfunction
Lead Investigator: Linda Dodds
Institution: Dalhousie University
Status: Complete
Investigated whether environmental chemicals, such as metals and pesticides, may contribute to a woman’s risk of developing gestational diabetes or gaining excess weight during pregnancy.
Exposure to free and conjugated forms of Bisphenol A (BPA) and Triclosan (TCS) during Pregnancy within the MIREC Study
Lead Investigator: Tye Arbuckle
Institution: Health Canada
Status: Complete
Developed new methods to measure urinary levels of several common chemicals (bisphenol A (BPA) and triclosan) found in consumer products and then analyzed 1st trimester urine samples from MIREC participants for these chemicals.
Exposure to Phenols, Phthalates and Pyrethroids in Young Children
Lead Investigator: Angelika Zidek
Institution: Health Canada
Status: Complete
Generated biomonitoring data on urinary concentrations of phthalates, phenols and pyrethroid pesticides for children under the age of three who participated in the MIREC-CD Plus Study.
Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic Health
Lead Investigator: Joe Braun
Institution: Brown University
Status: Ongoing
Examining associations between prenatal exposure to a common persistent group of chemicals (perfluoroalkyl substances (PFAS)) found in consumer products and adolescent metabolic health.
Impact of Maternal Weight and the Early Life Nutritional and Chemical Environments on Infant Cognitive Outcomes in the MIREC Pregnancy Cohort
Lead Investigator: Kristin Connor
Institution: Health Canada
Status: Complete
Investigated the links between maternal weight before and during pregnancy and child IQ.
Investigating links between environmental contaminant exposure and maternal metabolic health, including inflammation and pancreatic beta cell function
Lead Investigator: Jenny Bruin
Institution: Carleton University
Status: Ongoing
Investigating the association between a group of persistent chemicals (perfluoroalkyl substances (PFAS)) and maternal metabolic health ( inflammation and insulin secretion).
Maternal-Infant Research on Environmental Chemicals: Effects on Child Development at age 3 (MIREC-CD3)
Lead Investigator: Emmanuel Ouellet
Institution: Centre Hospitalier Universitaire de Québec (CHUQ)
Status: Complete
Measured different types of genetic variation among mothers participating in the MIREC Study, that may help explain observed differences in their health
MIREC Study: Maternal Biomonitoring
Lead Investigator: Tye Arbuckle
Institution: Health Canada
Status: Complete
Measured new and emerging chemicals in maternal urine from the 1st trimester to add to the list of chemicals that can be studied for potential health effects of mothers and their children.
MIREC: Associations between prenatal perfluoroalkyl substances (PFAS) and immune markers in offspring
Lead Investigator: Jillian Ashley-Martin
Institution: Health Canada
Status: Ongoing
Investigating how prenatal exposure to perfluoroalkyl substances (PFAS) may influence antibodies to common childhood diseases.
Neurodevelopmental Outcomes in Young Children Living in Areas With Fluoridated Versus Non-fluoridated Public Water
Lead Investigator: Christine Till
Institution: York University
Status: Complete
Investigated whether fluoride exposure during pregnancy and infancy is associated with IQ and behavioural outcomes in preschool-aged children.
Prenatal and Postnatal exposure to Per- and Polyfluoroalkyl substances, Placental efficiency, and Blood Pressure at early adolescence: The Multi-P Study
Lead Investigator: Gérard Ngueta
Institution: Université de Sherbrooke
Status: Ongoing
Assessing whether exposure to perfluoroalkyl substances (PFAS) during pregnancy and through breastfeeding is associated with blood pressure in children at ages 7 to 13.
Seroprevalence of Anti-Rubella and Anti-Pertussis IgG Antibodies in Canadian Pregnant Women
Lead Investigator: Nicolas Gilbert
Institution: Public Health Agency of Canada
Status: Complete
Measured antibodies against the rubella virus and the bacterium causing whooping cough in pregnant women. Researchers used this information to determine whether women were immune to these diseases.
Statistical approaches for estimating the effects of gestational exposure to environmental chemical mixtures in perinatal epidemiology
Lead Investigator: Lawrence McCandless
Institution: Simon Fraser University
Status: Complete
Identified the effects of various environmental chemical mixtures on the risk of preterm delivery, low birthweight, lower child IQ scores.
The Impact of Prenatal Exposure to Multiple Environmental Contaminants on Newborn Immune System Development
Lead Investigator: Jillian Ashley-Martin
Institution: Dalhousie University
Status: Complete
Investigated how prenatal exposure to several different environmental chemicals measured in umbilical cord blood may influence the developing fetal immune system.
The relationship between maternal folate and vitamin B12 status during pregnancy and fetal and early childhood development
Lead Investigator: Amanda Macfarlane & Joe Braun
Institution: Health Canada & Brown University
Status: Complete
Determined how gestational arsenic exposure impacts a child’s neurodevelopment and health, and examined how intake of folic acid and vitamin B12 during pregnancy can minimize adverse birth and child health outcomes.
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