41. Associations of prenatal urinary bisphenol A concentrations with child behaviors and cognitive abilities (abstract)

Braun JM, Muckle G, Arbuckle TE, Bouchard MF, Fraser WD, Ouellet E, Séguin JR, Oulhote Y, Webster GM, Lanphear BP. Environmental Health Perspectives 2017 Jun 16;125(6):067008. doi: 10.1289/EHP984


Prenatal bisphenol A (BPA) exposure has been associated with adverse neurodevelopment in epidemiological studies. However, prior studies had limited statistical power to examine sex-specific effects, and few examined child cognition.


We estimated the association between prenatal BPA exposure and child neurobehavior at 3 y of age in a prospective cohort of 812 mothers and their children.


We measured BPA concentration in urine samples collected at  ∼ 12 wk gestation among women enrolled in a 10-city Canadian cohort study. At approximately 3 y of age, we assessed children’s cognitive abilities with the Wechsler Primary and Preschool Scale of Intelligence™–III (WPPSI-III) and two scales of the Behavior Rating Inventory of Executive Function–Preschool (BRIEF-P). Parents reported children’s behavior using the Behavior Assessment System for Children–2 (BASC-2) and the Social Responsiveness Scale™ – 2. (SRS-2). We estimated covariate-adjusted differences in neurobehavioral outcomes with a doubling in BPA concentration and sex-specific associations.


BPA was not associated with WPPSI-III scores; child sex did not modify these associations. The association between BPA and BRIEF-P scores was modified by child sex (BPA × sex p – values ≤ 0.03). For example, a doubling of BPA concentration was associated with 1-point (95% CI: 0.3, 1.7) poorer working memory in boys and 0.5-point (95% CI: −1.1, 0.1) better scores in girls. BPA was not associated with most BASC-2 scales; however, it was associated with more internalizing and somatizing behaviors in boys, but not in girls (BPA × sex p – values ≤ 0.08). A doubling of BPA concentration was associated with poorer SRS-2 scores [β = 0.3 ( 95% CI: 0, 0.7)]; this association was not modified by sex.


Prenatal urinary BPA concentration was associated with some aspects of child behavior in this cohort, and some associations were stronger among boys. https://doi.org/10.1289/EHP984